A relatively common but nonpublicized acquired immune deficiency condition is often the primary cause of multiple episodes of recurrent sinusitis, bronchitis, pneumonia, and upper respiratory infections.  This condition is caused by low levels of selective subgroups of IgG, an immunoglobulin that is present in all patients. There are four differerent subgroups (IgG-1, IgG-2, IgG-3, and IgG-4) of the IgG immunoglobulin. The most common deficiency found in patients with sinus and infections described above usually have low levels of subgroups !gG-1 and IgG-3 but can occur with normal total IgG and low levels of other immunoglobulins (IgA, IgM, and IgE). This condition is called Common Variable Immune Deficiency (CVID). 

Many ENT patients afflicted with this disorder present with a history of multiple sinus infections or surgeries, mixed bacterial and fungal infections, and associated chronic nasal and sinus symptoms. Often these patients have a history of frequent or multiple surgeries, hospital admissions because of infections, or complications from the infections.

The treatment for CVID is monthly intravenous infusions of replacement IgG to return the deficient IgG subgroups or total IgG to normal levels. When this happens , the patient almost always experiences great symptom relief and the vicious cycle of infection is broken. Dr Sciacca has identified many patients with this disorder over the last several years. He refers these patients, when identified, to a known experienced hematologist or immunologist in this area. These specialist physicians  thoroughly evaluate and treat this disorder and rule out more serious types of immune deficiency states that may be present. 

If you, a family member, or friend has a history of refractory or resistant sinus, pulmonary, or respiratory infections as described above, please call our office for an appointment. Dr. Sciacca will perform a painless and complete HD video nasal endoscopic exam, DNA sinus cultures, and specific blood work to diagnose this perplexing disease and allow definiitive and often curative treatment.


4501 Southlake Pkwy
Suite #200
Hoover, AL 35244